Oxidative Stress: Biochemical and Pharmacological Aspects


The oxygen-, nitrogen- and sulfur-containing reactive species (respectively known as ROS, RNS and RSS) are subject to a tuned control in normal cells and tissues, where they play a role in the maintenance of redox homeostasis. An unbalance in these reactive species is a fingerprint of several diseases, including chronic infections, inflammatory disorders, vascular failure, neurodegeneration and cancer.

Biological activity of antioxidant molecules is crucial to counteract the overflow of reactive species in response to pro-oxidant insults; however, recent findings highlighted the Janus-faced properties of both free radicals and antioxidants, owing to the complexity of the cellular machinery involved in the response to oxidative stress.

The upgrade from in vitro studies to potential therapeutic applications of natural or synthetic antioxidants proved not to be straightforward, due to several aspects ranging from inefficient delivery and assimilation to paradoxical effects, revealing how challenging pharmacological recovery from an unbalanced redox homeostasis can be.

Deepening our knowledge on the molecular mechanisms underlying the modulation of ROS, RNS and RSS bioavailability, their crosstalk and interaction with antioxidant compounds is key to figure out how to sustain and possibly enhance the cell response to redox unbalance.

Finally, the identification of the key players in cell redox pathways and of new biological markers of oxidative stress is paramount to develop innovative diagnostic tools or pharmacological interventions against pathological conditions associated to persistent oxidative stress, with a view of criticism toward current trends of massive antioxidant consumption.

These topics will be addressed in a series of webinars where scientists actively working in the field will have the opportunity to share their recent research progresses.


Oxidative stress: biochemical and pharmacological aspects

24 June 2021

Barbara Tavazzi

Barbara Tavazzi
(Rome, Italy)

Marcello Allegretti

Marcello Allegretti
(L’Aquila, Italy)

Organising Committee

Alessandro Giuffrè

Alessandro Giuffrè


Elena Forte

Marzia Arese

Sapienza University of Rome

University of L'Aquila

Invited Speakers

Marcello Allegretti
(Dompè, L’Aquila, Italy)

D. Allan Butterfield
(University of Kentucky, Lexington, KY, USA)

Daniela Caporossi
(University of Rome “Foro Italico”, Italy)

Paola Chiarugi
(University of Florence, Italy)

Maria Rosa Ciriolo
(University of Rome “Tor Vergata”, Italy)

Marcus Conrad
(Helmholtz Zentrum München, Germany)

Antonio Cuadrado
(Autonomous University of Madrid, Spain)

Albena T. Dinkova-Kostova
(University of Dundee, UK)

Martin Feelisch
(University of Southampton, UK)

Omidreza Firuzi
(Shiraz University of Medical Sciences, Iran)

Ivan Gout
(University College London, UK)

Nadine Hempel
(Penn State University College of Medicine, USA)

Alessandro Leuti
(Campus Bio-Medico University of Rome, Italy)

Rebecca Oberley-Deegan
(University of Nebraska Medical Center, USA)

Paulo J. Oliveira
(University of Coimbra, Portugal)

Marzia Perluigi
(Sapienza University of Rome, Italy)

Douglas R. Spitz
(Cancer Center at the University of Iowa, USA)

Csaba Szabo
(University of Fribourg, Switzerland)

Fulvio Ursini
(University of Padua, Italy)

Barbara Tavazzi
(Catholic University of Rome, Italy)

João B. Vicente
(Universidade NOVA de Lisboa, Portugal)

Francesca Zazzeroni
(University of L’Aquila, Italy)

Mauro Maccarrone

Mauro Maccarrone, Dr. Enzymology and Bio-Organic Chemistry, is Professor and Chair of Biochemistry at the Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila (Italy). He is also Head of the Lipid Neurochemistry Unit at the European Center for Brain Research – IRCCS Santa Lucia Foundation, Rome. For his research activity he has received the “4th Royan International Research Award for Reproductive Biomedicine” (2003), the “2007 IACM Award for Basic Research”, the “2016 Mechoulam Award”, and the “2020 Tu Youyou Award”. Chair of the 2015 Gordon Research Conference on “Cannabinoid Function in the CNS”. Visiting Professor at Leiden University (Leiden Institute of Chemistry, The Netherlands) in 2017. Faculty member of The Lambert Center for the Study of Medicinal Cannabis and Hemp at Thomas Jefferson University in Philadelphia, since 2019. Visiting Professor at Cambridge University (Department of Psychology, U.K.) in 2019. Published more than 510 full papers, of which 60 with I.F. ≥ 9 (total I.F. > 2600; citations >18000, h-index = 70 according to Scopus). Listed among the Top Italian Scientists.

Luciano Saso

Prof. Luciano Saso ( is a Member of the Faculty of Pharmacy and Medicine, Sapienza University of Rome, Italy ( He is author of more than 250 original scientific articles published in peer reviewed international journals with impact factor (H-index Google Scholar = 49, H-index SCOPUS = 39, Total Impact Factor > 800) working mainly in the field of pharmacological modulation of oxidative stress. He coordinated several international research projects and has been referee for many national and international funding agencies and international scientific journals in the last 25 years. He has been Editor and Guest Editor of Special Issues of different international journals including ANTIOXIDANTS, JOURNAL OF PHARMACY AND PHARMACOLOGY, FRONTIERS IN PHARMACOLOGY, FRONTIERS IN CELLULAR NEUROSCIENCE, MOLECULES, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. More information is available at